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Infection was rarely implicated in the etiology of these lesions, although once an ulcer has developed, infection and PAD were found to be the major causes for amputation. 10,18,19 Many of the risk factors for foot ulcer are also predisposing factors for amputation, because ulcers …
CDC] 2015). Prediabetes is associated with an increased risk of cardiovascular disease, coronary heart disease, stroke, and all-cause mortality (Huang et al. 2016).If prediabetes is left untreated, 15% to 30% of people with it progress to type 2 diabetes within 5 y (American Medical Association and CDC 2015).Type 2 diabetes is a major contributor to morbidity, mortality, and health care costs ().
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The filtrate was concentrated to syrupy mass on a hot water bath (60°). Extraction with (2×20 ml) hot water, filtration and addition of HCl drop wise yielded a crystalline residue upon cooling in an ice bath for 30 min. Suction filtration and air drying gave the berberine enriched sample (20 mg).
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